Foreword. Introduction. Psychotherapy and the single synapse: the impact of psychiatric thought on neurobiologic research. A new intellectual framework for psychiatry. Biology and the future of psychoanalysis: a new intellectual framework for psychiatry revisited. From metapsychology to molecular biology: explorations into the nature of anxiety. Neurobiology and molecular biology: the second encounter. Neural science: a century of progress and the mysteries that remain. The molecular biology of memory storage: a dialog between genes and synapses. Genes, brains, and self-understanding: biology's aspirations for a new humanism. Afterword: psychotherapy and the single synapse revisited. Index.